Kaufman S, Mackay B J
J Physiol. 1983 Mar;336:73-81. doi: 10.1113/jphysiol.1983.sp014567.
A study was made of the responses of chronically hyperprolactinaemic rats to selected dipsogenic stimuli. Measurements were also made of the correlation between the state of hydration of the animal and the plasma prolactin levels. After 24 h water deprivation. S.C. isoprenaline (10 micrograms/kg body wt.) or I.P. injection (5 ml/kg body wt.) of a hypertonic solution (50% w/w) of polyethylene glycol (mol. wt 20000) there was no difference between the hyperprolactinaemic and control rats with respect to the total water intake, the time course of drinking or the urine output. After I.V. injection of 2 M-NaCl (5 ml/kg body wt.) there was no difference between the hyperprolactinaemic and control rats with respect to the total water intake or urine output. However, the hyperprolactinaemic rats drank more slowly than the controls. When angiotensin II was infused I.V. at a rate of 0.2 micrograms/min, the water intake was greater and the threshold to drinking lower in the hyperprolactinaemic than control rats. After 24 h water deprivation, plasma prolactin levels rose significantly in both the control and hyperprolactinaemic rats. When the rats were injected I.V. with hypertonic saline (5 ml, 2 M-NaCl/kg body wt.) and denied access to water, plasma prolactin levels had not changed 1 h later in either the control or hyperprolactinaemic animals. It is concluded that there is no interaction either between the plasma osmolality and prolactin secretion or between the plasma prolactin levels and the amount of water drunk in response to intracellular fluid deficits. However, prolactin secretion is stimulated by the combined intra- and extracellular deficits resulting from water deprivation and there is a clearly demonstrated interaction between prolactin and the extracellularly mediated stimulus of angiotensin II.
对慢性高催乳素血症大鼠对特定致渴刺激的反应进行了研究。还测量了动物的水合状态与血浆催乳素水平之间的相关性。在24小时禁水后，皮下注射异丙肾上腺素（10微克/千克体重）或腹腔注射（5毫升/千克体重）分子量为20000的聚乙二醇高渗溶液（50%重量/重量），高催乳素血症大鼠和对照大鼠在总饮水量、饮水时间进程或尿量方面没有差异。静脉注射2M氯化钠（5毫升/千克体重）后，高催乳素血症大鼠和对照大鼠在总饮水量或尿量方面没有差异。然而，高催乳素血症大鼠饮水比对照大鼠慢。当以0.2微克/分钟的速率静脉输注血管紧张素II时，高催乳素血症大鼠的饮水量更大，饮水阈值比对照大鼠低。24小时禁水后，对照大鼠和高催乳素血症大鼠的血浆催乳素水平均显著升高。当给大鼠静脉注射高渗盐水（5毫升，2M氯化钠/千克体重）并禁止其饮水时，1小时后对照动物和高催乳素血症动物的血浆催乳素水平均未改变。结论是，血浆渗透压与催乳素分泌之间或血浆催乳素水平与因细胞内液不足而饮水的量之间没有相互作用。然而，禁水导致的细胞内和细胞外联合不足刺激了催乳素分泌，并且催乳素与细胞外介导的血管紧张素II刺激之间存在明显的相互作用。
