Aviel A, Schwartz M
J Neurosci Res. 1983;9(4):459-65. doi: 10.1002/jnr.490090411.
Cranial idiopathic acute peripheral facial nerve paralysis (Bell palsy) has been used as a model disease in the present study mainly to investigate trophic capacity of serum components. The ability to induce sprouting from chick embryo dorsal root ganglia was used as the bioassay for trophic activity. Sera from normal patients induce neuritic outgrowth from dorsal root ganglia of chick embryo in the absence of any exogenous factor. Sprouting, to a very limited extent or none, has been induced by 80% of the sera derived from the Bell palsy patients. Further analysis of the biochemical nature of the reduced activity has revealed that in sera of Bell palsy patients the substances that are fractionated within the Ig fraction are responsible for the reduced capacity to induce sprouting without loss of supportive molecules.
在本研究中，颅部特发性急性周围性面神经麻痹（贝尔麻痹）主要被用作模型疾病，以研究血清成分的营养能力。将诱导鸡胚背根神经节发芽的能力用作营养活性的生物测定方法。正常患者的血清在没有任何外源性因素的情况下可诱导鸡胚背根神经节的神经突生长。80% 的贝尔麻痹患者血清仅能诱导非常有限程度的发芽或根本无法诱导发芽。对活性降低的生化性质进行的进一步分析表明，在贝尔麻痹患者的血清中，在免疫球蛋白（Ig）组分中分离出的物质是导致诱导发芽能力降低的原因，而支持分子并未丢失。
