Brondbo K, Hawke M, Abel S M, Alberti P W
J Otolaryngol. 1983 Jun;12(3):163-8.
Two-hundred and fifty years after Valsalva's discovery that fixation of the stapes could be a cause of deafness, there is still a lack of knowledge about the etiology and pathogenesis of otosclerosis. The purpose of this study was to obtain more information about the natural history of this disease by correlating the volumes and activity of otosclerotic lesions within the temporal bone to the patient's age and sex. Fifty temporal bones from 33 patients (19 females and 14 males) with otosclerotic lesions were reviewed microscopically. The degrees of activity of these foci were assessed and, using a computer based technique known as "digitizing", the volumes of each otosclerotic lesion were calculated. The results of this study indicate that there is no statistical difference in volumes between males and females. From the results obtained, it is suggested that there appear to be two growth patterns of the otosclerotic lesion: one pattern grows for a very short period and then becomes dormant or inactive. The other type of otosclerosis shows a continuing growth and progression throughout life.
在瓦尔萨尔瓦发现镫骨固定可能是耳聋的一个病因250年后，人们对耳硬化症的病因和发病机制仍然缺乏了解。本研究的目的是通过将颞骨内耳硬化病变的体积和活性与患者的年龄和性别相关联，来获得关于这种疾病自然史的更多信息。对33例（19例女性和14例男性）患有耳硬化病变患者的50块颞骨进行了显微镜检查。评估了这些病灶的活性程度，并使用一种称为“数字化”的基于计算机的技术计算了每个耳硬化病变的体积。本研究结果表明，男性和女性的体积之间没有统计学差异。从获得的结果来看，耳硬化病变似乎有两种生长模式：一种模式生长很短一段时间，然后变得静止或不活跃。另一种类型的耳硬化症在一生中呈现持续生长和进展。
