Waggie K S, Wagner J E, Lentsch R H
Lab Anim Sci. 1983 Jun;33(3):254-7.
B6C3F1 hybrid mice did not develop lesions of mycobacterial infection when intratracheally inoculated with a Mycobacterium avium-intracellulare complex organism isolated from a naturally occurring outbreak among C57BL/6N mice in a B6C3F1 hybrid production colony. Young C57BL/6N females did not develop lesions when comingled with naturally infected adult C57BL/6N mice. After subcutaneous or oral inoculation of the isolate into 8-week-old and adult 36- to 40-week-old C57BL/6N mice, it was found that the subcutaneous route yielded a higher percentage of culture positive lungs and animals with gross and microscopic pulmonary lesions than the oral route of inoculation. Adult mice were more susceptible to infection than 8-week-old animals.
当用从B6C3F1杂交生产群体中自然爆发的C57BL/6N小鼠分离出的鸟分枝杆菌-胞内分枝杆菌复合菌经气管内接种B6C3F1杂交小鼠时，它们并未出现分枝杆菌感染病变。年轻的C57BL/6N雌性小鼠与自然感染的成年C57BL/6N小鼠混养时并未出现病变。将该分离株皮下或口服接种到8周龄和36至40周龄的成年C57BL/6N小鼠后，发现皮下接种途径产生的培养阳性肺以及有肉眼和显微镜下肺部病变的动物百分比高于口服接种途径。成年小鼠比8周龄动物更易感染。
