Ginsburg R, Davis K, Bristow M R, McKennett K, Kodsi S R, Billingham M E, Schroeder J S
Lab Invest. 1983 Aug;49(2):154-8.
We tested the effects of the calcium antagonists lanthanum, diltiazem, and flunarizine on the development of atherosclerosis in rabbits fed a 2% cholesterol diet. The drugs were given orally and were well tolerated. In the cholesterol control animals, 52.2% of the thoracic aortic intimal surface was Sudan IV positive. This was reduced by 37% (p less than 0.05) with lanthanum, 37% (p less than 0.05) with diltiazem, and 34% (p less than or equal to 0.06) with flunarizine. In all cholesterol-fed animals, the intramural, but not subepicardial, coronary arteries were severely diseased. The extent and distribution of this disease were not altered by the various drug interventions. Thus, the calcium antagonists lanthanum, diltiazem, and flunarizine suppress atherogenesis of the rabbit aorta but have no effect on the extent or distribution of atherosclerosis in the intramural coronary arteries.
我们测试了钙拮抗剂镧、地尔硫䓬和氟桂利嗪对喂食2%胆固醇饮食的家兔动脉粥样硬化发展的影响。这些药物通过口服给药，耐受性良好。在胆固醇对照组动物中，胸主动脉内膜表面52.2%呈苏丹IV阳性。镧使其降低了37%（p<0.05），地尔硫䓬使其降低了37%（p<0.05），氟桂利嗪使其降低了34%（p≤0.06）。在所有喂食胆固醇的动物中，壁内冠状动脉而非心外膜下冠状动脉严重病变。这种疾病的程度和分布并未因各种药物干预而改变。因此，钙拮抗剂镧、地尔硫䓬和氟桂利嗪可抑制家兔主动脉的动脉粥样硬化形成，但对壁内冠状动脉粥样硬化的程度或分布没有影响。
