大剂量环磷酰胺、阿霉素联合达卡巴嗪维持治疗转移性软组织肉瘤。
High-dose cyclophosphamide and adriamycin with DTIC maintenance for metastatic soft tissue sarcomas.
作者信息
Clamon G, Sinkey C, Jochimsen P
出版信息
J Surg Oncol. 1983 Aug;23(4):282-4. doi: 10.1002/jso.2930230413.
PMID:6876805
Abstract
Intensive chemotherapy with high-dose cyclophosphamide and adriamycin with DTIC maintenance was given to 12 patients with metastatic soft tissue sarcomas. A partial response rate of 25% was seen; this is no better than can be achieved with single-agent therapy. Because of substantial toxicity without improved efficacy, the trial of high dose therapy was halted.
摘要
对12例转移性软组织肉瘤患者给予大剂量环磷酰胺、阿霉素强化化疗并联合达卡巴嗪维持治疗。观察到部分缓解率为25%；这并不比单药治疗所能达到的效果更好。由于毒性大且疗效未改善，高剂量治疗试验停止。
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