[Effect of tolbutamide on the electrical activity of bursting neurons in Helix pomatia].

The effect of tolbutamide, an inhibitor of proteinkinase reaction, on electrical activity of the RPal bursting neuron was studied in Helix pomatia. It is shown that 5 mM tolbutamide produced a complete and reversible block of pacemaker activity of the neuron. It is concluded that cell proteinkinase is involved in the genesis of neuronal bursting activity.