Altered sensitivity of forebrain neurones to iontophoretically applied noradrenaline in aging rats.
作者信息
Jones R S, Olpe H R
出版信息
Neurobiol Aging. 1983 Spring;4(1):97-9. doi: 10.1016/0197-4580(83)90060-x.
PMID:6877492
Abstract
Responses of unidentified neurones in the rostral cerebral cortex to iontophoretically applied noradrenaline and GABA were compared in young (3-4 months old) and old (22-24 months old) albino rats. Depressant responses to noradrenaline were smaller in the older animals and this was manifested particularly as a decrease in response duration. Depressant responses to GABA did not differ significantly in the two groups. The results indicate that neurones in the cerebral cortex, as in the cerebellum, exhibit a decrease in postsynaptic responsiveness to noradrenaline with advancing age.
摘要
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