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Metergoline as a selective 5-hydroxytryptamine antagonist in the cerebral cortex.

作者信息

Sastry B S, Phillis J W

出版信息

Can J Physiol Pharmacol. 1977 Feb;55(1):130-3. doi: 10.1139/y77-020.

DOI:10.1139/y77-020
PMID:843988
Abstract

In rats anaesthetized with a mixture of methoxyflurane, nitrous oxide, and oxygen, the depressant actions on the cerebral cortical neurones of iotophoretically applied 5-hydroxytryptamine (5-HT) but not of noradrenaline, histamine, AMP Ca2+, and gamma-aminobutyric acid were antagonized by metergoline. These observations indicate that metergoline may be a selective 5-HT antagonist in the cerebral cortex.

摘要

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