铝对血液透析患者甲状旁腺激素水平的影响。
The influence of aluminium on parathyroid hormone levels in haemodialysis patients.
作者信息
Cannata J B, Briggs J D, Junor B J, Beastall G, Fell G S
出版信息
Proc Eur Dial Transplant Assoc. 1983;19:244-7.
In order to investigate the relationship between parathyroid hormone (PTH) and aluminium we studied 86 haemodialysis patients whom we separated into three groups according to their serum PTH values. Group I: PTH less than 600ng/L; Group II: PTH 600-900ng/L; Group III: PTH greater than 900ng/L. A significant difference was found between Groups I and III in the serum aluminium (Group I: 4.85 mumol/L; Group III: 2.84 mumol/L, p less than 0.003) and serum calcium (Group I: 2.43mmol/L; Group III: 2.32mmol/L, p less than 0.0125). The association of higher serum aluminium and calcium with lower PTH concentrations suggests that aluminium can suppress PTH release through an elevation of the serum calcium.
为了研究甲状旁腺激素（PTH）与铝之间的关系，我们对86例血液透析患者进行了研究，并根据他们的血清PTH值将其分为三组。第一组：PTH低于600ng/L；第二组：PTH为600 - 900ng/L；第三组：PTH高于900ng/L。在血清铝（第一组：4.85μmol/L；第三组：2.84μmol/L，p小于0.003）和血清钙（第一组：2.43mmol/L；第三组：2.32mmol/L，p小于0.0125）方面，第一组和第三组之间存在显著差异。血清铝和钙升高与较低的PTH浓度相关，这表明铝可以通过升高血清钙来抑制PTH的释放。
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