DeVenuto F, Zegna A I
Prog Clin Biol Res. 1983;122:29-39.
The development and evaluation of an effective Hb solution as a blood substitute are important not only for the care of casualties resulting from mass disasters, but also for eventual use in other special clinical situations. Substantial improvements have been made in recent years in the quality of Hb solutions. Solutions of unmodified Hb, although with certain limitations as indicated, potentially could be useful in several applications. The limitations presented by unmodified Hb can be overcome by a modification of the Hb molecule. In oxygen transport, not only the flow of the vascular fluid but also the vascular retention time, the oxygen affinity, and the concentration of free circulating Hb are important. A solution of Pyr-Poly Hb possesses positive characteristics in regard to the last three of these factors and, if the possibility of using bovine Pyr-Poly Hb is considered, the problem of supply for the material needed for the stockpiling of large quantities of this resuscitating solution can be eliminated. Products obtained by such modification must be evaluated also for their safety so that no potential adverse clinical effects would develop when administered to human patients.
开发和评估一种有效的血红蛋白溶液作为血液替代品不仅对于大规模灾难造成的伤亡救治很重要，而且对于最终在其他特殊临床情况中的应用也很重要。近年来血红蛋白溶液的质量有了实质性的改进。未修饰的血红蛋白溶液，尽管有所述的某些局限性，但在一些应用中可能会有用。未修饰的血红蛋白所呈现的局限性可以通过对血红蛋白分子进行修饰来克服。在氧运输中，不仅血管内液体的流动，而且血管滞留时间、氧亲和力以及游离循环血红蛋白的浓度都很重要。聚吡咯血红蛋白溶液在上述后三个因素方面具有积极特性，并且如果考虑使用牛聚吡咯血红蛋白的可能性，那么储备大量这种复苏溶液所需材料的供应问题就可以消除。通过这种修饰获得的产品还必须评估其安全性，以便在给人类患者使用时不会产生潜在的不良临床影响。
