Gould S A, Rosen A L, Sehgal L R, Sehgal H L, Moss G S
Prog Clin Biol Res. 1983;122:331-42.
In summary, we remain optimistic about the potential value of perfluorochemicals as acellular oxygen carriers. The results of our first patient show that at an FiO2 of 1.0, Fluosol-DA was not necessary. The oxygen content of the plasma alone was adequate, although the FiO2 was at an unsafe level. At the safe FiO2 of 0.6, however, the Fluosol-DA was needed, since the oxygen content of the plasma was inadequate. Fluosol-DA was thus necessary and effective. At an FiO2 = 0.6, the total of the oxygen content of plasma and the oxygen content of Fluosol-DA was adequate. Although these results are encouraging, the temporary nature of this benefit is an important limitation. We hope that the additional data from both our clinical study and the multicenter study will help resolve some of these questions in the future.
总之，我们仍对全氟化合物作为无细胞氧载体的潜在价值持乐观态度。我们首例患者的结果表明，在吸入氧分数为1.0时，全氟萘烷双棕榈酸酯并非必要。仅血浆中的氧含量就足够了，尽管吸入氧分数处于不安全水平。然而，在安全的吸入氧分数0.6时，就需要全氟萘烷双棕榈酸酯，因为血浆中的氧含量不足。因此，全氟萘烷双棕榈酸酯是必要且有效的。在吸入氧分数 = 0.6时，血浆中的氧含量与全氟萘烷双棕榈酸酯中的氧含量之和是足够的。尽管这些结果令人鼓舞，但这种益处的暂时性是一个重要的局限性。我们希望来自我们的临床研究和多中心研究的更多数据将有助于在未来解决其中一些问题。
