Hall R D, Macrides F
Physiol Behav. 1983 May;30(5):797-803. doi: 10.1016/0031-9384(83)90180-4.
Previous studies had shown that transection of the lateral olfactory tracts and lesions of the septohippocampal system were similar in the deficits they engendered in nest building and food piling or hoarding by hamsters. The present investigation asked whether olfactory lesions would also produce deficits in radial-maze behavior like those associated with septo-hippocampal lesions. Radical olfactory bulbectomy led to a marked deterioration in preoperatively trained behavior in an 8-arm radial maze. The behavioral changes resembled those resulting from septo-hippocampal lesions in three ways: (1) There were fewer choices of adjacent arms and more choices of more distant arms. (2) Choice accuracy as a function of successive choices within a trial declined more rapidly. (3) The probability of repeating choice sequences was abnormally high. Earlier studies had shown that the rat does not require olfactory cues to perform efficiently in radial mazes. It therefore seems likely that the deficits described here resulted from the disruption of interconnections between the olfactory and septo-hippocampal systems rather than from the loss of olfactory sensitivity.
先前的研究表明，切断外侧嗅束以及损伤隔海马系统，在对仓鼠筑巢和食物堆积或贮藏能力造成的缺陷方面是相似的。本研究探讨嗅觉损伤是否也会像隔海马损伤那样，导致放射状迷宫行为出现缺陷。彻底切除嗅球导致术前经过训练的八臂放射状迷宫行为显著恶化。行为变化在三个方面类似于隔海马损伤所导致的变化：（1）相邻臂的选择减少，较远臂的选择增多。（2）作为一次试验中连续选择函数的选择准确性下降得更快。（3）重复选择序列的概率异常高。早期研究表明，大鼠在放射状迷宫中高效执行任务并不需要嗅觉线索。因此，这里所描述的缺陷似乎是由于嗅觉系统与隔海马系统之间的联系中断所致，而非嗅觉敏感性丧失所致。
