Quintana A, Raczka E, Giralt M T, Quintana M A
Prostaglandins. 1983 Apr;25(4):549-56. doi: 10.1016/0090-6980(83)90027-8.
The purpose of this work was to evaluate the effects of equipotent doses of two different inhibitors of cyclo-oxygenase, indomethacin and aspirin, on cerebral blood flow and cerebral vascular resistances in the conscious undisturbed rat, using the reference sample radioactive microsphere method. We found that both, aspirin (50 mg/kg) and indomethacin (5 mg/kg) at 3, 15 and 60 min after their intravenous administration, increased cerebral vascular resistances and decreased cerebral blood flow to a similar extent. Both drugs completely abolished the hypotensive effect of 5 mg/kg i.v. arachidonic acid and they did not change arterial PO2, PCO2 or pH values. We conclude that the pharmacological inhibition of cyclooxygenase in the conscious undisturbed rat leads to a cerebral vasoconstriction and consequently to a decrease in cerebral blood flow. Our results evidence that prostaglandins are a physiological factor that actively contributes to the maintenance of cerebral circulation.
本研究旨在采用参比样品放射性微球法，评估等剂量的两种不同环氧化酶抑制剂（吲哚美辛和阿司匹林）对清醒未受干扰大鼠脑血流量和脑血管阻力的影响。我们发现，静脉注射阿司匹林（50 mg/kg）和吲哚美辛（5 mg/kg）后3分钟、15分钟和60分钟，二者均使脑血管阻力增加，脑血流量减少，且程度相似。两种药物均完全消除了静脉注射5 mg/kg花生四烯酸所致的降压作用，且未改变动脉血氧分压、二氧化碳分压或pH值。我们得出结论，在清醒未受干扰的大鼠中，环氧化酶的药理抑制作用会导致脑血管收缩，进而引起脑血流量减少。我们的结果表明，前列腺素是积极维持脑循环的生理因素。
