哺乳动物神经内分泌细胞中的爆发式放电涉及一种内在的再生机制。
Burst discharge in mammalian neuroendocrine cells involves an intrinsic regenerative mechanism.
作者信息
Andrew R D, Dudek F E
出版信息
Science. 1983 Sep 9;221(4615):1050-2. doi: 10.1126/science.6879204.
PMID:6879204
Abstract
Intracellular recordings from mammalian neuroendocrine cells showed that steady, injected currents can modify and block periodic spike bursts previously associated with increased neurohormone release. Spike afterpotentials could sum to form plateau potentials, which generated bursts and did not depend on axonal conduction or chemical synapses. Therefore, bursting involves a spike-dependent, positive-feedback mechanism endogenous to single neuroendocrine cells.
摘要
对哺乳动物神经内分泌细胞进行的细胞内记录显示，稳定的注入电流可以改变并阻断先前与神经激素释放增加相关的周期性尖峰爆发。尖峰后电位可以总和形成平台电位，该电位产生爆发，且不依赖于轴突传导或化学突触。因此，爆发涉及单个神经内分泌细胞内源性的依赖于尖峰的正反馈机制。
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