Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
J Neuroendocrinol. 2021 Nov;33(11):e13042. doi: 10.1111/jne.13042. Epub 2021 Nov 8.
The plain title might have been an almost retro sounding grumpy retort, but it has inspired a journey of sorts, and something along the way I hope you won't have come across before. An opinionated exploration of the distinctive phasic spiking patterns of magnocellular vasopressin neurons of the supraoptic and paraventricular nuclei of the hypothalamus. A mostly life essential population of neurons that signal the kidneys to regulate water loss in response to signals that encode plasma volume and osmotic pressure, as well as regulating blood pressure, and possibly metabolism and social behaviour. The viewpoint of a modeller shorn of any explicit maths.
这个朴实无华的标题可能听起来有点复古和脾气暴躁，但它激发了我进行了一次探索之旅，希望你在探索过程中不会遇到之前从未见过的东西。这是对下丘脑视上核和室旁核大细胞加压素神经元独特的相位尖峰模式的一种固执己见的探索。这些神经元大多是生命必需的神经元，它们向肾脏发出信号，根据编码血浆容量和渗透压的信号来调节水的流失，同时还调节血压，可能还有代谢和社会行为。这是一个没有任何明确数学内容的建模者的观点。
