Wehmann R E, Rubenstein H A, Pugeat M M, Nisula B C
South Med J. 1983 Aug;76(8):969-76. doi: 10.1097/00007611-198308000-00007.
We have developed a radioimmunoassay for thyroid-stimulating hormone (TSH) that is sufficiently sensitive to permit reliable measurement of subnormal serum TSH levels. We report our evaluation of the utility of this radioimmunoassay in the diagnosis and management of thyroid disease. In 59 normal subjects, the mean serum TSH level was 1.49 +/- 0.10 microU/ml (mean +/- SEM) with the range 0.5 to 4.5 microU/ml. In patients without pituitary-hypothalamic lesions, the serum TSH level accurately reflected thyroid status, being subnormal in 29 hyperthyroid patients, supranormal in 26 hypothyroid patients, and normal in 31 euthyroid patients being treated for nonthyroid conditions. In patients being treated for either hyperthyroidism or hypothyroidism, the serum TSH level appeared to be a sensitive indicator of thyroid status, and its return to normal appeared to be a useful therapeutic criterion. We conclude that improving the sensitivtity and reliability of the serum TSH radioimmunoassay greatly extends its clinical applications.
我们已经开发出一种用于促甲状腺激素（TSH）的放射免疫测定法，其灵敏度足以可靠地测量低于正常水平的血清TSH浓度。我们报告了对这种放射免疫测定法在甲状腺疾病诊断和管理中的效用评估。在59名正常受试者中，血清TSH平均水平为1.49±0.10微单位/毫升（平均值±标准误），范围为0.5至4.5微单位/毫升。在无垂体-下丘脑病变的患者中，血清TSH水平准确反映了甲状腺状态，29例甲状腺功能亢进患者低于正常水平，26例甲状腺功能减退患者高于正常水平，31例因非甲状腺疾病接受治疗的甲状腺功能正常患者TSH水平正常。在接受甲状腺功能亢进或减退治疗的患者中，血清TSH水平似乎是甲状腺状态的敏感指标，其恢复正常似乎是一个有用的治疗标准。我们得出结论，提高血清TSH放射免疫测定法的灵敏度和可靠性可大大扩展其临床应用。
