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[普罗司匹定在全身性淋巴肉芽肿病复发联合化疗中的应用]

[Use of prospidin in the combination chemotherapy of recurrences of generalized forms of lymphogranulomatosis].

作者信息

Vinokurova N A, Danova L A, Kondrat'ev V B, Gershanovich M L

出版信息

Vopr Onkol. 1983;29(7):46-50.

PMID:6880132
Abstract

Combined chemotherapy (prospidin, cyclophosphamide, vincristine and prednisolone) (PCVP) was given to 32 patients with recurrent generalized forms of Hodgkin's disease. Remission was reliably established in 75% of patients; its mean duration was 2.8 months. 15 patients received repeated courses of complex chemotherapy, including prospidin; it proved effective in 12 of them. Mean duration of remission was 2.7 months. Toxic side--effects were insignificant and subsided quickly. The results of the study point to the effectiveness of PCVP scheme application in patients with recurrent generalized forms of Hodgkin's disease.

摘要

对32例复发性全身性霍奇金病患者给予联合化疗(丙亚胺、环磷酰胺、长春新碱和泼尼松)(PCVP)。75%的患者可靠地实现了缓解;缓解的平均持续时间为2.8个月。15例患者接受了包括丙亚胺在内的重复多疗程化疗;其中12例证明有效。缓解的平均持续时间为2.7个月。毒副作用不明显且很快消退。该研究结果表明PCVP方案应用于复发性全身性霍奇金病患者是有效的。

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