[Occurrence of antibodies against influenza viruses in the lung, bile and sera of mice following aerogenous infection and oral or subcutaneous immunization].

Antibodies against influenza viruses were detected by enzymimmunoassay (ELISA) in sera, lung lavage fluids and biles from Balb/c-mice infected by aerosol route or immunized subcutaneously and orally. In both immunized groups antibodies occurred in the bile. In infected animals first antibodies in sera were detectable on day 7 post infectionem (p.i.), in lung lavage fluids on day 11 p.i. Subcutaneous immunization led to lower antibody titers in lung lavage fluid than the oral route of immunization, but to inverse relations in sera. There was no relation between individual antibody titers in sera and lung lavage fluid after oral immunization, supporting the concept of local antibody secretion after remote-site stimulation in the intestinal tract.