Fritze U, Fritze D, Bicker U, Ewald R W, Friedberg K D
Z Rheumatol. 1983 May-Jun;42(3):101-3.
We utilized a new, whole blood method to study the stimulation of lymphocytes by phytohemagglutinin in patients with rheumatoid arthritis and healthy volunteers. We observed that lymphocytes of patients with rheumatoid arthritis were significantly less stimulated by phytohemagglutinin than lymphocytes of controls (p less than 0.05). The underlying T-cell defect appeared to be present at all stages and activity levels of disease, and in both seropositive and seronegative patients.
我们采用了一种全新的全血方法，来研究类风湿性关节炎患者和健康志愿者体内植物血凝素对淋巴细胞的刺激作用。我们观察到，与对照组的淋巴细胞相比，类风湿性关节炎患者的淋巴细胞受植物血凝素的刺激明显较少（p小于0.05）。潜在的T细胞缺陷似乎在疾病的所有阶段和活动水平均存在，并且在血清阳性和血清阴性患者中都存在。
