Greitz T, Andreen M, Irestedt L
Acta Anaesthesiol Scand. 1983 Jun;27(3):211-7. doi: 10.1111/j.1399-6576.1983.tb01937.x.
High epidural block (Th I-IV) with bupivacaine was carried out in 16 dogs. Mean arterial blood pressure decreased to 52% of control value owing to nearly equal decreases in systemic vascular resistance and cardiac output. Portal venous blood flow decreased from 25.8 +/- 8.6 to 16.7 +/- 7.2 ml/kg b.w. X min-1 following epidural block, while hepatic arterial blood flow remained unchanged at 9.1 +/- 3.1 ml/kg b.w. X min-1 owing to a reduction in hepatic arterial resistance of 51%. Hepatic oxygen uptake was maintained during the epidural block through increased oxygen extraction. However, total oxygen uptake decreased by 18% and, in spite of this, arteriovenous oxygen content difference increased by 25%, indicating circulatory depression.
对16只狗实施了布比卡因高位硬膜外阻滞（胸段I-IV）。平均动脉血压降至对照值的52%，这是由于全身血管阻力和心输出量近乎同等程度降低所致。硬膜外阻滞后，门静脉血流量从25.8±8.6降至16.7±7.2 ml/kg体重×min-1，而肝动脉血流量维持在9.1±3.1 ml/kg体重×min-1不变，这是因为肝动脉阻力降低了51%。在硬膜外阻滞期间，通过增加氧摄取维持了肝脏的氧摄取。然而，总氧摄取减少了18%，尽管如此，动静脉氧含量差仍增加了25%，表明存在循环抑制。
