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氨苄青霉素口服给药方法对犊牛血浆药物浓度影响的研究。

A study of the influence of the method of oral administration of ampicillin upon plasma drug levels in calves.

作者信息

Thompson S M, Black W D

出版信息

Can J Comp Med. 1978 Jul;42(3):255-9.

PMID:688070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1277636/
Abstract

Ampicillin was given orally to five Holstein calves using the following four different methods of administration: via stomach tube, mixed and fed in the calf starter ration, dissolved in milk and pail fed and administered orally as 400 mg commercial calf tablets. In addition, ampicillin was dissolved in milk and pail fed 20 to 30 minutes following intramuscular atropine. Ampicillin was only detected in the plasma of calves which had received the drug, pail fed in milk. Atropine administration slowed the appearance of the drug in the plasma but did not decrease the efficiency of absorption.

摘要

使用以下四种不同给药方法对五头荷斯坦犊牛口服氨苄西林

通过胃管给药、混入犊牛开食料中喂食、溶解于牛奶中用桶喂服以及口服400毫克市售犊牛片剂。此外,在肌肉注射阿托品后20至30分钟,将氨苄西林溶解于牛奶中用桶喂服。仅在通过牛奶用桶喂服药物的犊牛血浆中检测到氨苄西林。阿托品的使用减缓了药物在血浆中的出现,但并未降低吸收效率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeae/1277636/48c3386cff70/compmed00031-0010-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeae/1277636/48c3386cff70/compmed00031-0010-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeae/1277636/48c3386cff70/compmed00031-0010-a.jpg

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The route of liquids administered to calves by esophageal feeder.通过食管饲管给犊牛投喂液体的途径。

本文引用的文献

1
Reflex contraction of the oesophageal groove in young ruminants.幼龄反刍动物食管沟的反射性收缩
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Microbiological studies on a new broad-spectrum penicilin, "Penbritin".对新型广谱青霉素“氨苄青霉素”的微生物学研究。
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The distribution of orally administered ampicillin in calves.
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The effects of feeding procedure on closure of the oesophageal groove in young sheep.饲养程序对幼羊食管沟闭合的影响。
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Visual studies of the oesophageal groove in lambs and its response to intravenous atropine.羔羊食管沟的视觉研究及其对静脉注射阿托品的反应。
J Anat. 1970 Jan;106(Pt 1):199.
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The distribution of a 400 mg. dose of ampicillin administered orally to calves.
Vet Rec. 1972 Apr 22;90(17):476-8. doi: 10.1136/vr.90.17.476.
10
Effects of vagotomy, atropine, hexamethonium and adrenaline on the destination in the stomach of liquids sucked by milk-fed lambs and calves.迷走神经切断术、阿托品、六甲铵和肾上腺素对以奶为食的羔羊和犊牛所吸液体在胃内去向的影响。
J Physiol. 1974 Mar;237(2):415-30. doi: 10.1113/jphysiol.1974.sp010489.