Berg E, Lindelius R, Petterson U, Salum I
Acta Psychiatr Scand. 1983 Jun;67(6):389-98. doi: 10.1111/j.1600-0447.1983.tb09719.x.
The study comprises 20 men who had shown admixtures of schizophrenic and affective symptoms during their first hospitalisation in a psychiatric hospital in Stockholm 1946-1957. The observation period was between 17 and 30 years. At the time of follow-up the group was rediagnosed on the basis of all information obtained. It was shown that this originally relatively homogeneous group was made up of a heterogeneous collection of illnesses. Definite schizophrenia formed the largest group (nine patients). Three patients had developed a definite manic-depressive disease and three severe alcoholism. The remaining five patients showed prominent symptoms of both schizophrenic and affective type. After the first hospitalisation 19 patients were recovered or improved. At the end of the follow-up period the corresponding number was eight. Twelve patients showed social recovery, i.e. were working or studying at the end of the follow-up period. Eighteen patients were at some time re-hospitalised for psychosis. The group, as a whole, spent 16% of the observation period hospitalised in a mental hospital - 6% in the outcome group recovered + improved and 21% in the outcome group were unimproved. The course was difficult to predict with the aid of factors usually considered prognostically favourable. The study stresses the need for prospective controlled studies based on a systematised after-care programme for patients who show symptoms of both schizophrenia and affective illness in their first attack.
该研究包括20名男性，他们在1946年至1957年于斯德哥尔摩一家精神病院首次住院期间表现出精神分裂症和情感症状的混合。观察期为17至30年。在随访时，根据所获得的所有信息对该组进行了重新诊断。结果显示，这个原本相对同质的组由一系列异质性疾病组成。明确的精神分裂症患者构成最大的组（9名患者）。3名患者发展为明确的躁狂抑郁症，3名患有严重酒精中毒。其余5名患者表现出精神分裂症和情感型的突出症状。首次住院后，19名患者康复或病情改善。随访期结束时，相应的数字为8名。12名患者实现了社会康复，即在随访期结束时正在工作或学习。18名患者曾因精神病再次住院。总体而言，该组在观察期内有16%的时间住院治疗——在康复+改善的结果组中为6%，在未改善的结果组中为21%。借助通常被认为对预后有利的因素很难预测病程。该研究强调需要对首次发作时表现出精神分裂症和情感疾病症状的患者，基于系统化的后续护理计划进行前瞻性对照研究。
