Casey L C, Ballantyne H K, Fletcher J R, Chernow B, Lake C R
Adv Shock Res. 1983;9:233-7.
A nonhuman primate model of exposure-induced hypothermia was developed and the hemodynamic effects of hypothermia were evaluated in five animals. With decreasing core temperature from 37 degrees C to 33 degrees C there was a 47% increase in heart rate, a 23% increase in mean arterial pressure, a 48% increase in cardiac output, a 260% increase in oxygen consumption, and a 237% increase in minute ventilation. As the core temperature decreased from 33 degrees C to 29 degrees C there were decreases in the heart rate, blood pressure, and cardiac output such that at 29 degrees C these values were not significantly different from the values obtained at 37 degrees C. However, the oxygen consumption was still 180% increased and the minute ventilation 40% higher at 29 degrees C than at 37 degrees C. This model will allow the evaluation of the physiology of hypothermia and the effectiveness of different rewarming techniques.
建立了暴露诱导性体温过低的非人灵长类动物模型，并在五只动物身上评估了体温过低对血流动力学的影响。随着核心体温从37℃降至33℃，心率增加47%，平均动脉压增加23%，心输出量增加48%，耗氧量增加260%，分钟通气量增加237%。当核心体温从33℃降至29℃时，心率、血压和心输出量均下降，以至于在29℃时这些值与在37℃时获得的值无显著差异。然而，在29℃时耗氧量仍比37℃时增加180%，分钟通气量比37℃时高40%。该模型将有助于评估体温过低的生理学以及不同复温技术的有效性。
