Weaver L C, Meckler R L, Fry H K, Donoghue S
Am J Physiol. 1983 Aug;245(2):R241-50. doi: 10.1152/ajpregu.1983.245.2.R241.
Reflex effects of cardiac sympathetic afferent nerve excitation on cardiac and renal components of sympathetic outflow have been well investigated, but the extent of these cardiac afferent influences on other sympathetic nerves or on respiratory or cortical neural systems is unknown. Therefore such influences were investigated electrophysiologically in anesthetized, vagotomized, baroreceptor-denervated cats. Stimulation of cardiac sympathetic spinal afferent neurons by the noxious substance bradykinin caused excitation of cardiac, renal, splenic, gastrohepatic, adrenal, and deep peroneal (muscle) vasoconstrictor sympathetic nerves, as well as excitation of phrenic nerves and concomitant desynchronization of the electroencephalogram. Possible supraspinal pathways mediating these responses were investigated. Sympathetic reflexes caused by cardiac afferent stimulation were unchanged after decerebration, thereby demonstrating that supramedullary mediation was not essential to the sympathetic responses. Potential contributions of the medulla to the observed sympathetic or other responses were demonstrated by recording from medullary neurons responsive to electrical and chemical stimulation of the afferent nerves. In summary, noxious stimulation of cardiac sympathetic afferent neurons leads to widespread neural excitation which may contribute to sensory, visceral, and somatic responses caused by cardiac pain or which occur during activated states such as exercise or emotional stress.
心脏交感传入神经兴奋对交感神经传出的心脏和肾脏部分的反射效应已得到充分研究，但这些心脏传入神经对其他交感神经或呼吸或皮层神经系统的影响程度尚不清楚。因此，在麻醉、迷走神经切断、压力感受器去神经支配的猫身上用电生理学方法研究了这种影响。用有害物质缓激肽刺激心脏交感脊髓传入神经元，可引起心脏、肾脏、脾脏、胃肝、肾上腺和腓深（肌肉）血管收缩交感神经的兴奋，以及膈神经的兴奋和脑电图的同步化。研究了介导这些反应的可能的脊髓上通路。心脏传入刺激引起的交感反射在大脑切除后没有改变，从而表明脊髓上的介导对交感反应不是必需的。通过记录对传入神经的电刺激和化学刺激有反应的延髓神经元，证明了延髓对观察到的交感或其他反应的潜在贡献。总之，对心脏交感传入神经元的有害刺激会导致广泛的神经兴奋，这可能有助于由心脏疼痛引起的感觉、内脏和躯体反应，或在运动或情绪应激等激活状态下发生的反应。
