Comparison of bladder carcinogenesis by nitrosomethyldodecylamine in Sprague--Dawley and Fischer rats carrying transplanted bladder tissue.

Nitrosomethyldodecylamine was given by gavage in oliver oil solution (25 mg twice/week) to male and female Sprague--Dawley and Fischer rats to the back of each of which had been transplanted a suspension of urinary bladder tissue from the same strain. While there was 100% incidence of transitional cell carcinomas in the host urinary bladders, and few other tumors in the animals, there was a tumor in only 1 transplant in a Sprague--Dawley rat, with a possible tumor in another, and none in the Fischer rat, although these were inbred. In a significant number of cases the transplant survived.