13-cis-Retinoic acid: inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.
作者信息
Grubbs C J, Moon R C, Squire R A, Farrow G M, Stinson S F, Goodman D G, Brown C C, Sporn M B
出版信息
Science. 1977 Nov 18;198(4318):743-4. doi: 10.1126/science.910158.
PMID:910158
Abstract
Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder.
摘要
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