Bissonnette B, Beaudet F
Ann Rheum Dis. 1983 Aug;42(4):466-8. doi: 10.1136/ard.42.4.466.
A 17-year-old Cambodian-born female was recently evaluated for subacute seronegative arthritis involving both ankles and the right midfoot. Suboptimal response to a nonsteroidal anti-inflammatory drug prompted open synovial biopsy, which showed intensive eosinophilic infiltration of the synovial structures. Slight peripheral eosinophilia had been found before her admission to hospital, and Ankylostoma duodenale was isolated. Antiparasitic treatment offered little more relief. She was also found out to be a carrier of the histocompatibility antigen HLA B27, and it may be that despite unusual histological findings she had a B27-related reactive type of arthropathy. The relation to the parasitic infestation remains speculative.
一名17岁出生于柬埔寨的女性最近因累及双踝和右中足的亚急性血清阴性关节炎接受评估。对非甾体抗炎药反应欠佳促使进行开放性滑膜活检，结果显示滑膜结构有密集的嗜酸性粒细胞浸润。入院前发现有轻度外周血嗜酸性粒细胞增多，并分离出十二指肠钩口线虫。抗寄生虫治疗几乎没有带来更多缓解。还发现她是组织相容性抗原HLA B27携带者，尽管组织学检查结果不寻常，但她可能患有一种与B27相关的反应性关节病。与寄生虫感染的关系仍属推测。
