MacMillan W E, Wolberg W H, Welling P G
Cancer Res. 1978 Oct;38(10):3479-82.
A high-pressure liquid chromatography method has been used to investigate the pharmacokinetics of fluorouracil after single i.v. doses to patients. The method is simple and is specific for fluorouracil. No interference was observed in fluorouracil determinations due to other administered medication. Plasma levels of fluorouracil declined rapidly after dosing. The mean half-life was 11.4 min, and drug was essentially cleared from plasma in 1 hr. Individual differences in plasma fluorouracil levels, and also in derived pharmacokinetic constants, were considerably less than those reported previously.
已采用高压液相色谱法研究氟尿嘧啶单次静脉注射给药后在患者体内的药代动力学。该方法简单且对氟尿嘧啶具有特异性。在测定氟尿嘧啶时未观察到其他给药药物的干扰。给药后氟尿嘧啶的血浆水平迅速下降。平均半衰期为11.4分钟，药物在1小时内基本从血浆中清除。血浆氟尿嘧啶水平以及推导的药代动力学常数的个体差异明显小于先前报道的差异。
