Fujita K, Nagatsu T, Shinpo K, Maruta K, Takahashi H, Sekiya A
Cancer Res. 1978 Oct;38(10):3509-11.
A significant increase in putrescine was noted in the urine of mice with experimental s.c. tumors induced by a single injection of 3,4-benzopyrene solution (2.52 mg of 3,4-benzopyrene in 0.5 ml of tricaprylin). When 10 mg of putrescine were added to the 3,4-benzopyrene solution, the development of tumors was completely inhibited and the increase of urinary putrescine in mice was suppressed simultaneously. Animal weight data of a control group receiving only putrescine indicated that the inhibitory effect of putrescine is not due to its toxicity.
单次注射3,4-苯并芘溶液（0.5 ml三辛酸甘油酯中含2.52 mg 3,4-苯并芘）诱导产生实验性皮下肿瘤的小鼠尿液中，腐胺显著增加。当向3,4-苯并芘溶液中添加10 mg腐胺时，肿瘤生长完全受到抑制，同时小鼠尿液中腐胺的增加也受到抑制。仅接受腐胺的对照组动物体重数据表明，腐胺的抑制作用并非源于其毒性。
