Kim D N, Lee K T, Schmee J, Thomas W A
Atherosclerosis. 1983 Jul;48(1):1-13. doi: 10.1016/0021-9150(83)90013-8.
When young swine are fed a suitable hyperlipidemic (HL) diet the number of cells in intimal cell masses (ICM) of large and medium-sized arteries begins to increase in number; by 90 days on the diet the cell increase is several-fold compared to no significant increase in cell numbers in ICM of mash-fed controls. The objective of the current study was to see if the cell increase associated with the HL diet could be reduced by pyridinolcarbamate or aspirin. Arteries studied were the abdominal aorta and the coronaries; time on HL diet was 90 days. Both drugs resulted in significant reductions in the increases in cells in ICM associated with the HL diet in both of the arterial beds that were studied. The reduction was most prominent in the abdominal aorta where the increase in ICM cells in the untreated HL diet-fed swine was from an average of 242 +/- 50 cells per cross-section in the mash-fed controls to 1925 +/- 556; in the pyridinolcarbamate-treated swine the increase was only to 641 +/- 214 and in the aspirin-treated group to 770 +/- 146.
给幼猪喂食合适的高脂血症（HL）日粮时，大中型动脉内膜细胞团（ICM）中的细胞数量开始增加；在喂食该日粮90天时，细胞数量增加了数倍，而相比之下，以糊状饲料喂养的对照猪的ICM中细胞数量没有显著增加。本研究的目的是观察吡多卡胺或阿司匹林是否可以减少与HL日粮相关的细胞增加。所研究的动脉为腹主动脉和冠状动脉；HL日粮喂养时间为90天。在两个研究的动脉床中，两种药物均显著减少了与HL日粮相关的ICM中细胞的增加。这种减少在腹主动脉中最为明显，在未治疗的HL日粮喂养猪中，ICM细胞的增加从糊状饲料喂养对照猪的平均每横截面积242±50个细胞增加到1925±556个；在吡多卡胺治疗的猪中，增加仅为641±214个，在阿司匹林治疗组中增加到770±146个。
