慢性给予氧烯洛尔对正常血压和高血压大鼠主动脉壁的影响。

Effect of the chronic administration of oxprenolol on the aortic wall of the normotensive and hypertensive rats.

作者信息

Pauletto P, Terribile Wiel Marin V, Santandrea S, Scannapieco G, Vescovo G, Dario C, Pessina A C

出版信息

Boll Soc Ital Biol Sper. 1983 May 30;59(5):667-73.

Abstract

4 groups of male Wistar rats were studied: - normotensive control rats (4 animals) treated with s.c. water - normotensive rats (6 animals) treated with s.c. 5 mg/Kg Oxprenolol - hypertensive control rats (renal artery stenosis) (6 animals) treated with s.c. water - hypertensive rats (renal artery stenosis) (9 animals) treated with s.c. 5 mg/Kg Oxprenolol. The animals were treated and/or operated at six weeks of age and sacrificed at 12 weeks of age. Blood Pressure (BP), Heart Rate (HR), Ventricular Mass (VM) and Thickness of the Aortic Media (A Th) were determined. Oxprenolol did reduce HR but not BP in both normotensive and hypertensive rats: these animals showed a reduced A Th but not a reduced VM compared with untreated control rats. These results suggest a direct effect of Oxprenolol on A Th independently from BP values, but not on VM.

摘要

对4组雄性Wistar大鼠进行了研究：- 皮下注射水的正常血压对照大鼠（4只动物）- 皮下注射5 mg/Kg氧烯洛尔的正常血压大鼠（6只动物）- 皮下注射水的高血压对照大鼠（肾动脉狭窄）（6只动物）- 皮下注射5 mg/Kg氧烯洛尔的高血压大鼠（肾动脉狭窄）（9只动物）。这些动物在6周龄时接受治疗和/或手术，并在12周龄时处死。测定了血压（BP）、心率（HR）、心室质量（VM）和主动脉中层厚度（A Th）。在正常血压和高血压大鼠中，氧烯洛尔确实降低了心率，但没有降低血压：与未治疗的对照大鼠相比，这些动物的A Th降低了，但VM没有降低。这些结果表明，氧烯洛尔对A Th有直接作用，独立于血压值，但对VM没有作用。