青霉素对家兔脑电图的影响。

The effects of penicillin on the ECoG of rabbit.

作者信息

Musolino R, Gallitto G, Bianchi L, Santoro M, Bonanzinga M, De Domenico P, Di Stefano G, Di Perri R

出版信息

Boll Soc Ital Biol Sper. 1983 May 30;59(5):697-703.

Abstract

The effects of non-convulsive doses of i.v. penicillin (1.100.000/1.300.000 I.U./Kg) on the ECoG of rabbits was studied. A tendency to an increase in spindling activity together with the presence of characteristic penicillin spikes, polyspikes and spike and wave complexes often preceding or intermixed to the spindling activity, was the most prominent finding. These data indicate that spindles and penicillin induced spikes show a straight correlation and seem consistent with the hypothesis that spindles have a facilitant effect on epileptic discharges.

摘要

研究了静脉注射非惊厥剂量的青霉素（1,100,000/1,300,000国际单位/千克）对家兔脑电图（ECoG）的影响。最显著的发现是，纺锤波活动有增加的趋势，同时存在特征性的青霉素棘波、多棘波以及常常先于纺锤波活动出现或与之混合的棘慢复合波。这些数据表明，纺锤波与青霉素诱导的棘波呈直接相关，似乎与纺锤波对癫痫放电有促进作用的假说一致。