Getova D, Moyanova S
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Methods Find Exp Clin Pharmacol. 1988 Apr;10(4):267-72.
The effects of barbiturate HB-7 (2-hydroxylamine-5-ethyl-5-sec-pentylbarbituric acid) injected intraperitoneally compared to the effects of pentobarbital and/or phenobarbital were investigated in three series of experiments on cats: normal electrocorticogram (ECoG); pentylentetrazol-induced generalized paroxysmal ECoG; and paroxysmal ECoG activity induced by topical application of penicillin on the exposed cortical surface. In the first series, HB-7 led to the appearance of ECoG spindles of the same type as those elicited by pentobarbital. In the second series (pentylentetrazol-treated group), HB-7 increased the two thresholds: one associated with the appearance of isolated paroxysmal spike-wave complexes and the other corresponding to the appearance of generalized paroxysmal ECoG activity. In the third series, HB-7 led to an inhibition of penicillin spikes, both in the focus itself and in the other cortical areas where they propagated. The possibility for using HB-7 as an antiepileptic drug was discussed.
在对猫进行的三组实验中，研究了腹腔注射巴比妥酸盐HB - 7（2 - 羟胺 - 5 - 乙基 - 5 - 仲戊基巴比妥酸）与戊巴比妥和/或苯巴比妥的作用相比的效果：正常脑电图（ECoG）；戊四氮诱导的全身性阵发性ECoG；以及在暴露的皮质表面局部应用青霉素诱导的阵发性ECoG活动。在第一组实验中，HB - 7导致出现与戊巴比妥引起的相同类型的ECoG纺锤波。在第二组实验（戊四氮治疗组）中，HB - 7提高了两个阈值：一个与孤立的阵发性棘波 - 慢波复合波的出现相关，另一个与全身性阵发性ECoG活动的出现相对应。在第三组实验中，HB - 7导致青霉素棘波在其起源部位以及它们传播到的其他皮质区域均受到抑制。讨论了将HB - 7用作抗癫痫药物的可能性。
