Chirkov G P, Boĭkov P Ia, Druzhinina M K, Todorov I N
Biokhimiia. 1983 Jun;48(6):975-82.
Ribosomal RNA synthesis in starved rat liver cells after a single injection of sublethal dose of cycloheximide (3 mg per kg of body weight) was studied. An increase in the rate of nuclear ribosomal RNA synthesis was observed during the first 2 hours after cycloheximide injection followed by a noticeable decrease of synthesis by the 3rd hour. It was assumed that the stimulation of ribosomal RNA synthesis is correlated with the increase in the rate of transport from the cytoplasm to the nuclei of RNP proteins and of proteins involved in regulation of genome transcription.
研究了单次注射亚致死剂量环己酰亚胺（每千克体重3毫克）后饥饿大鼠肝细胞中核糖体RNA的合成情况。注射环己酰亚胺后的前2小时，观察到核糖体RNA合成速率增加，随后在第3小时合成显著下降。据推测，核糖体RNA合成的刺激与RNP蛋白以及参与基因组转录调控的蛋白从细胞质向细胞核的转运速率增加有关。
