Mojarad M, Hamasaki Y, Said S I
Bull Eur Physiopathol Respir. 1983 May-Jun;19(3):253-6.
Platelet-activating factor, a naturally occurring lipid that is released from leukocytes and alveolar macrophages, increased the flow of protein-rich lymph from the lungs and induced pulmonary edema in dogs when given in picomolar doses. The pulmonary edema was due to increased microvascular permeability, probably secondary to endothelial cell injury. These observations suggest that platelet-activating factor may be a mediator of high-permeability pulmonary edema in the "respiratory distress syndrome" complicating acute lung injury.
血小板活化因子是一种天然存在的脂质，可从白细胞和肺泡巨噬细胞中释放出来，当以皮摩尔剂量给予时，会增加狗肺部富含蛋白质的淋巴液流动并诱发肺水肿。肺水肿是由于微血管通透性增加，可能继发于内皮细胞损伤。这些观察结果表明，血小板活化因子可能是急性肺损伤并发的“呼吸窘迫综合征”中高通透性肺水肿的介质。
