Kirsch-Volders M, Hens L, Ashley T, Verschaeve L, Susanne C
Can J Genet Cytol. 1983 Jun;25(3):304-11. doi: 10.1139/g83-048.
The method of "generalized distances" was applied to compare the effects on homologous interchromosomal distances of colcemid, the routinely used tubulin inhibitor with the effects of two other metaphase arrestants: nocodazole, also a tubulin inhibitor and cycloheximide, an inhibitor of protein synthesis which preserves somatic association. More homologous pairs were associated in the cycloheximide treatment than in the other two procedures; however, while several chromosomes which tend to lie toward the center of the metaphase plate showed somatic association in the various treatments, we found no evidence for somatic association of the larger, more peripherally located chromosomes in human cells in any of our treatments (chromosome pair 7 excepted in the colcemid sample).
运用“广义距离”方法比较了秋水仙酰胺（常用的微管蛋白抑制剂）、另外两种中期阻滞剂（诺考达唑，也是一种微管蛋白抑制剂；环己酰亚胺，一种能维持体细胞联会的蛋白质合成抑制剂）对同源染色体间距离的影响。与其他两种处理相比，环己酰亚胺处理中有更多同源染色体对发生联会；然而，尽管在各种处理中，几条倾向于位于中期板中心的染色体显示出体细胞联会，但在我们的任何处理中，均未发现人类细胞中较大的、更位于外周的染色体存在体细胞联会的证据（秋水仙酰胺样本中的7号染色体对除外）。
