Dahl O, Mella O
Cancer. 1983 Sep 15;52(6):983-7. doi: 10.1002/1097-0142(19830915)52:6<983::aid-cncr2820520609>3.0.co;2-w.
The interaction of hyperthermia (HT) 1 hour at 44.0 degrees C and cyclophosphamide (CP) 200 mg/kg was studied in vivo in a solid transplantable neurogenic rat tumor (BT4A) in the foot of BD IX rats. HT was given by water bath heating. When both modalities were close in time (CP immediately before HT or 1 hour before HT), an enhanced effect with complete regression and cure of tumors was seen. This could not be obtained with either modality alone. Extending the interval between treatments within 24 hours, an effect equal to the sum of each modality was obtained when HT was given before CP, while HT after CP was less effective. Timing and sequence may be critical factors for the optimal combination of HT and cytotoxic drugs.
在BD IX大鼠足部的可移植性实体神经源性大鼠肿瘤（BT4A）中，对44.0摄氏度下1小时的热疗（HT）与200 mg/kg环磷酰胺（CP）之间的相互作用进行了体内研究。通过水浴加热进行热疗。当两种治疗方式在时间上接近时（CP在热疗前立即给药或在热疗前1小时给药），可观察到肿瘤完全消退和治愈的增强效果。单独使用任何一种治疗方式均无法获得此效果。在24小时内延长治疗间隔，当热疗在环磷酰胺之前进行时，可获得与每种治疗方式效果之和相当的效果，而环磷酰胺之后进行热疗则效果较差。时间安排和顺序可能是热疗与细胞毒性药物最佳组合的关键因素。
