Effect of hyperthermia on a neurogenic rat cell line (BT4A) in vivo.

The effect of hyperthermia alone on the growth of the BT4A neurogenic tumour implanted into the feet of BD IX rats has been investigated. Following treatment by immersion of the tumour-bearing leg in a water bath at 42.0 to 45.0 degrees C a temporary retardation of tumour growth was observed but no cure. The lag phase before regrowth occurred was temperature and time dependent. A log-liner correlation was found between the surviving fraction previously found in vitro and the heat sensitivity of the cell line in vivo.