Fischer S M, Hardin L G, Slaga T J
Cancer Lett. 1983 Jun;19(2):181-7. doi: 10.1016/0304-3835(83)90152-0.
Diazepam (Valium) had previously been shown to enhance the growth rate of some transplantable tumors although studies in other systems have suggested an inhibitory effect. Skin tumor promotion studies were therefore carried out to determine the effect of diazepam on 12-O-tetradecanoyl phorbol-13-acetate (TPA) promotion in SENCAR mice. A sex-independent dose response inhibition occurred over a dose range of 100 g to 5 mg, both in number of papillomas and percent of mice bearing tumors. Furthermore, a dose-response reduction in tumor size was observed. By itself, diazepam had no tumor promoting activity.
地西泮（安定）先前已被证明可提高某些可移植肿瘤的生长速率，尽管在其他系统中的研究表明其具有抑制作用。因此，开展了皮肤肿瘤促进研究，以确定地西泮对SENCAR小鼠中12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）促进作用的影响。在100μg至5mg的剂量范围内，无论是乳头状瘤数量还是患肿瘤小鼠的百分比，均出现了与性别无关的剂量反应抑制。此外，还观察到肿瘤大小的剂量反应性减小。地西泮本身没有肿瘤促进活性。
