Switch on and switch off phenomenon of liver gluconeogenic function in lamprey (Lampetra fluviatilis L.) under the influence of season and temperature.

The potential activity of pyruvate carboxylase in lamprey liver is the same as in mammals. However, at certain stages of the life cycle this reaction does not take place because of ATP deficiency in mitochondria. Energy charge potential of liver cells ranges from 0.76 to 0.11 throughout a year. Heat adaptation of lampreys leads to a rapid increase of the ATP level and of the NAD+/NADH ratio in liver. The intensity of gluconeogenesis and glycogen levels are also enhanced. Cold reacclimation reverses the effect. A scheme accounting for the temperature changes in energy status of hepatocytes has been proposed.