Savina M V, Derkachev E F
Comp Biochem Physiol B. 1983;75(3):531-9. doi: 10.1016/0305-0491(83)90371-1.
The potential activity of pyruvate carboxylase in lamprey liver is the same as in mammals. However, at certain stages of the life cycle this reaction does not take place because of ATP deficiency in mitochondria. Energy charge potential of liver cells ranges from 0.76 to 0.11 throughout a year. Heat adaptation of lampreys leads to a rapid increase of the ATP level and of the NAD+/NADH ratio in liver. The intensity of gluconeogenesis and glycogen levels are also enhanced. Cold reacclimation reverses the effect. A scheme accounting for the temperature changes in energy status of hepatocytes has been proposed.
七鳃鳗肝脏中丙酮酸羧化酶的潜在活性与哺乳动物相同。然而，在生命周期的某些阶段，由于线粒体中ATP缺乏，该反应无法进行。肝细胞的能荷电位全年在0.76至0.11之间变化。七鳃鳗的热适应导致肝脏中ATP水平和NAD⁺/NADH比值迅速增加。糖异生的强度和糖原水平也会增强。冷驯化则会逆转这种效应。已经提出了一个解释肝细胞能量状态温度变化的方案。
