Saksena S, White M J, Mertzlufft J, Lau I
Contraception. 1983 May;27(5):521-30. doi: 10.1016/0010-7824(83)90049-5.
The potential of zinc (Zn) to antagonize the adverse effects of cadmium (Cd) on the male reproductive processes was studied. A significant reduction in the weights of the testis and epididymis, the testicular sperm population and oligospermia to azoospermia in the epididymis was recorded in rats treated once s.c. with 2 mg/kg Cd and sacrificed 20 days later. This was accompanied by a significantly reduced serum T and a loss of fertility. Administration of a single s.c. injection of Zn (80 mg/kg) did not alter significantly any of the reproductive parameters studied. On the other hand, Zn given 1/2 to 2 h after Cd resulted in partial recovery. Organ weights and sperm population in these groups were maintained and the fertility rate was 67% and 50% at 5 and 20 days as compared to 67% and 0% at corresponding period in Cd-exposed males. The protective effect diminished when Zn was given more than 2 h after Cd exposure. The most effective regimen of Zn therapy was an administration of a total dose of 80 mg/kg Zn given in 3 injections (15 mg/kg before, 50 mg/kg at the time and 15 mg/kg 2 h after Cd). The results provide evidence that Zn, if given before or within 2 h of Cd exposure, is capable of at least partially reversing its deleterious effects on spermatogenesis, steroidogenesis and fertility of the male rat.
研究了锌（Zn）拮抗镉（Cd）对雄性生殖过程不利影响的潜力。单次皮下注射2mg/kg Cd并在20天后处死的大鼠，睾丸和附睾重量、睾丸精子数量显著减少，附睾中出现少精子症至无精子症。同时伴有血清睾酮显著降低和生育力丧失。单次皮下注射锌（80mg/kg）对所研究的任何生殖参数均无显著改变。另一方面，在镉注射后1/2至2小时给予锌可导致部分恢复。这些组的器官重量和精子数量得以维持，在5天和20天时生育率分别为67%和50%，而镉暴露雄性大鼠在相应时期的生育率分别为67%和0%。在镉暴露后2小时以上给予锌时，保护作用减弱。锌治疗最有效的方案是分3次注射给予总剂量80mg/kg锌（镉注射前15mg/kg、同时50mg/kg、镉注射后2小时15mg/kg）。结果表明，如果在镉暴露前或暴露后2小时内给予锌，至少能够部分逆转其对雄性大鼠精子发生、类固醇生成和生育力的有害影响。
