Niccoli L, Bellandi M, Benedini G, Cuccia C, Petroboni V, Visioli O
Eur Heart J. 1983 Apr;4(4):280-5. doi: 10.1093/oxfordjournals.eurheartj.a061460.
In 30 patients undergoing coronary angiography the effects of Iopamidol on sinus node activity, atrioventricular and intraventricular conduction were evaluated using His Bundle recordings, and compared to the effects produced by Diatrizoate. Diatrizoate resulted in an increase in sinus cycle length and prolonged AV nodal conduction, resulting in second degree AV block in two patients. Iopamidol had significantly less effect on sinus cycle (P less than 0.01) and AV nodal conduction (P less than 0.01). Neither contrast media affected intraventricular conduction. No difference was noted in the imaging power of the two contrast media. It is suggested that non-ionic, low osmotic contrast media such as Iopamidol will result in increased patient safety during coronary angiography without loss of imaging power.
在30例接受冠状动脉造影的患者中，使用希氏束记录评估了碘帕醇对窦房结活动、房室传导和室内传导的影响，并与泛影葡胺产生的影响进行了比较。泛影葡胺导致窦性周期长度增加，房室结传导延长，两名患者出现二度房室传导阻滞。碘帕醇对窦性周期（P<0.01）和房室结传导（P<0.01）的影响明显较小。两种造影剂均不影响室内传导。两种造影剂的成像能力没有差异。提示非离子型、低渗性造影剂如碘帕醇在冠状动脉造影期间可提高患者安全性，且不损失成像能力。
