Nori D, Cain J M, Hilaris B S, Jones W B, Lewis J L
Gynecol Oncol. 1983 Aug;16(1):117-28. doi: 10.1016/0090-8258(83)90017-3.
Advanced vulvovaginal cancers have a survival of less than 25% in 5 years when treated with radiotherapy alone. The radiosensitizer metronidazole was used with unconventional radiation fractions in 10 patients. Local control was achieved in 9 out of 10 patients treated. Five of 10 patients have remained free of disease 9-30 months postdiagnosis. Two patients died with metastatic disease, but with local control. In only 1 patient did this approach fail to control local disease. The outcome of these 10 patients represents a significant improvement over conventional radiation. A randomized prospective study has been started on the basis of this pilot study.
晚期外阴阴道癌单纯接受放射治疗时，5年生存率低于25%。对10例患者使用放射增敏剂甲硝唑并采用非常规放疗分割方式。接受治疗的10例患者中有9例实现了局部控制。10例患者中有5例在确诊后9至30个月无疾病复发。2例患者死于转移性疾病，但局部得到了控制。只有1例患者这种方法未能控制局部疾病。这10例患者的治疗结果相较于传统放疗有显著改善。基于这项初步研究已启动一项随机前瞻性研究。
