Higuchi N, Kyogoku Y, Shin M, Inouye K
Int J Pept Protein Res. 1983 May;21(5):541-5. doi: 10.1111/j.1399-3011.1983.tb02681.x.
The n.m.r. pattern of triostin A in weakly polar solvents was explained by the presence of two symmetrical conformers. Its S-benzyl derivative still shows the n.m.r. pattern of two conformers, while des-N-tetramethyltriostin A, which lacks the N-methyl groups, gives one conformer. Therefore the slow interconversion of two conformers arises from the cis-trans isomerization of the N-methyl peptide bonds, but not from the reversal of the chirality around the S-S bond. Only one of the two conformers of triostin A interacts with adenosine and guanosine derivatives. Des-N-tetramethyltriostin A can also interact with the purine nucleosides, but more preferentially with the adenosine derivative.
曲菌素A在弱极性溶剂中的核磁共振图谱可通过两种对称构象体的存在来解释。其S-苄基衍生物仍显示出两种构象体的核磁共振图谱，而缺乏N-甲基基团的去-N-四甲基曲菌素A则给出一种构象体。因此，两种构象体之间缓慢的相互转化源于N-甲基肽键的顺反异构化，而非二硫键周围手性的反转。曲菌素A的两种构象体中只有一种与腺苷和鸟苷衍生物相互作用。去-N-四甲基曲菌素A也能与嘌呤核苷相互作用，但更倾向于与腺苷衍生物相互作用。
