Nusrat A, Tepper D, Hertzberg J, Sonnenblick E H, Aronson R S
J Clin Pharmacol. 1983 Jul;23(7):257-65. doi: 10.1002/j.1552-4604.1983.tb02733.x.
The effects of amrinone on conduction in the intact canine heart were studied. Intracardiac His-electrode catheter recordings were used to measure the functional refractory period (FRP) of the AV node and conduction time through the AV node (A2H2 interval) and in the His-Purkinje system (H2V2 interval). Amrinone (2.5 to 10 mg/kg) shortened the FRP and A2H2 in a dose-dependent manner but had no significant effect on H2V2. In hearts where AV conduction was depressed by treatment with verapamil, propranolol, or ouabain, amrinone partially reversed this depression. Amrinone also shortened the recovery time of spontaneous sinoatrial (SA) node activity following a train of rapid atrial stimulation. This effect was also observed after depression of SA nodal recovery with verapamil, propranolol, or ouabain. These results indicate that amrinone enhances AV conduction and SA nodal activity in the normal heart and may favorably influence depressed AV conduction and SA nodal activity induced by a variety of cardioactive agents.
研究了氨力农对完整犬心脏传导的影响。采用心内希氏电极导管记录法来测量房室结的功能不应期（FRP）、通过房室结的传导时间（A2H2间期）以及在希氏-浦肯野系统中的传导时间（H2V2间期）。氨力农（2.5至10毫克/千克）以剂量依赖方式缩短了FRP和A2H2，但对H2V2无显著影响。在用维拉帕米、普萘洛尔或哇巴因治疗使房室传导受抑制的心脏中，氨力农可部分逆转这种抑制作用。氨力农还缩短了一串快速心房刺激后窦房结自发活动的恢复时间。在用维拉帕米、普萘洛尔或哇巴因抑制窦房结恢复后也观察到了这种效应。这些结果表明，氨力农可增强正常心脏的房室传导和窦房结活动，并可能对由多种心脏活性药物引起的房室传导抑制和窦房结活动抑制产生有利影响。
