Athanassenas G, Papadopoulos E, Kourkoubas A, Tsitourides S, Gabriel J, Hoïdas S, Frangos E
J Clin Psychopharmacol. 1983 Aug;3(4):212-6.
Serum calcium and magnesium levels were studied during neuroleptic treatment in a group of 29 chronic schizophrenic inpatients who had previously remained drug free for at least 4 weeks. The drug-free values of both electrolytes were not significantly different between patients and controls. In three patients who developed catatonic stupor during the drug-free period, calcium was significantly increased at the onset of the catatonic manifestations. Both electrolytes were significantly decreased in the whole group during treatment; the magnitude of the decrease was independent of the neuroleptic used. No correlation was found between the observed increase in prolactin and calcium changes. Patients who remained free of extra-pyramidal symptoms had a higher mean drug-free magnesium to calcium ratio compared to those who developed such symptoms. Our study provides evidence for an interconnection between serum electrolyte changes and neuroleptic drug action.
对一组29名慢性精神分裂症住院患者进行了抗精神病药物治疗期间血清钙和镁水平的研究，这些患者此前至少4周未使用药物。患者和对照组这两种电解质的未用药值无显著差异。在3名在未用药期间出现紧张性木僵的患者中，在紧张性表现开始时钙显著升高。治疗期间全组两种电解质均显著降低；降低幅度与所用抗精神病药物无关。观察到的催乳素升高与钙变化之间未发现相关性。与出现锥体外系症状的患者相比，未出现锥体外系症状的患者平均未用药时镁与钙的比值更高。我们的研究为血清电解质变化与抗精神病药物作用之间的相互联系提供了证据。
