Ellis M E, Mandal B K
J Infect. 1983 Jan;6(1):17-28. doi: 10.1016/s0163-4453(83)95426-9.
Ten years' experience of a Regional Centre for Infectious Diseases in the use of hyperbaric oxygen in 87 patients have been reviewed. Its efficacy in the treatment of non-infectious cases has been confirmed. Fifty-eight (67 per cent) patients had anaerobic infections associated with peripheral vascular disease, limb trauma, abdominal surgery or occurred spontaneously. All patients had failed to respond to surgery and antimicrobial agents, and were transferred for hyperbaric treatment as the infection was progressive. Marked improvement in general condition, wound infection and limitation of extension of the anaerobic infection occurred following hyperbaric treatment. These improvements had benefits in terms of surgical risk, demarcation and mortality. Symptoms suggestive of oxygen toxicity occurred in up to 24 per cent of all patients, but in many this took the form of anxiety and anxiety-related symptoms. Despite the beneficial effects of hyperbaric oxygen, many surgeons appear to be unaware or sceptical of the facility. A prospective controlled trial is advocated.
对一家地区传染病中心10年来对87例患者使用高压氧的经验进行了回顾。其在非感染性病例治疗中的疗效得到了证实。58例（67%）患者患有与周围血管疾病、肢体创伤、腹部手术相关或自发发生的厌氧菌感染。所有患者对手术和抗菌药物均无反应，由于感染呈进行性发展，被转至高压氧治疗。高压氧治疗后，患者的一般状况、伤口感染及厌氧菌感染扩展受限均有明显改善。这些改善在手术风险、界限划分和死亡率方面均有益处。高达24%的患者出现了提示氧中毒的症状，但其中许多表现为焦虑及与焦虑相关的症状。尽管高压氧有有益作用，但许多外科医生似乎并不了解或怀疑这种治疗手段。提倡进行一项前瞻性对照试验。
