Aperia A, Marin L, Zetterström R, Günöz H, Neyzi O, Saner G, Sökücü S
J Pediatr. 1983 Sep;103(3):364-9. doi: 10.1016/s0022-3476(83)80404-1.
Changes in sodium balance and urinary and stool output during orally administered rehydration therapy were studied in 22 well-nourished Turkish infants, aged 2 to 13 months, with acute diarrhea mainly of viral origin. The infants randomly received a rehydration solution containing either 90 mmol Na/L (ORS90) or 40 mmol Na/L (ORS40). Slight transient hypernatremia was noted in a few infants receiving ORS90, and slight transient hyponatremia in a few infants receiving ORS40. In both groups, sodium balance increased most rapidly during the first 12 hours of rehydration, and then more slowly because of increased urinary as well as stool sodium output. Sodium balance was always more positive after ORS90 than after ORS40, but the difference did not change much from 12 to 36 hours after therapy was started. Changes in fractional sodium excretion, urinary K/Na quotient, and urinary aldosterone-creatinine quotient were used as indexes of changes in sodium balance. All values were interpreted to indicate that the sodium deficit on admission was corrected within 12 to 18 hours after ORS90 and, in most cases, after 24 to 36 hours after ORS40. Both groups of infants responded well to orally administered rehydration therapy from the clinical viewpoint.
对22名营养良好、年龄在2至13个月的土耳其婴儿进行了研究，这些婴儿患有主要由病毒引起的急性腹泻，研究内容为口服补液治疗期间钠平衡以及尿液和粪便排出量的变化。婴儿被随机给予含90 mmol Na/L（ORS90）或40 mmol Na/L（ORS40）的补液溶液。接受ORS90的少数婴儿出现轻微短暂高钠血症，接受ORS40的少数婴儿出现轻微短暂低钠血症。两组中，补液治疗的前12小时内钠平衡增加最快，之后由于尿钠和粪钠排出量增加而增速放缓。ORS90治疗后的钠平衡始终比ORS40治疗后更正向，但治疗开始后12至36小时内差异变化不大。钠排泄分数、尿钾/钠比值和尿醛固酮-肌酐比值的变化被用作钠平衡变化的指标。所有数值均表明，ORS90治疗后12至18小时内入院时的钠缺乏得到纠正，大多数情况下，ORS40治疗后24至36小时内钠缺乏得到纠正。从临床角度看，两组婴儿对口服补液治疗反应良好。
