Andreani A, Scapini G, Galatulas I, Bossa R
J Pharm Sci. 1983 Jul;72(7):814-5. doi: 10.1002/jps.2600720724.
The reaction between o-hydroxybutyrophenone and tris(2-chloroethyl)amine gave two analogues (II, V) of the well-known local anesthetic ketocaine (I). Compounds II and V showed interesting antitumor activity in mice implanted with Ehrlich ascites tumor cells (% T/C = 149 at 5 mg/kg and 171 at 50 mg/kg, respectively). Further studies on the pharmacological behavior of these new compounds are in progress.
邻羟基苯丁酮与三（2-氯乙基）胺反应生成了两种著名局部麻醉剂酮卡因（I）的类似物（II、V）。化合物II和V在接种艾氏腹水瘤细胞的小鼠中显示出有趣的抗肿瘤活性（分别在5毫克/千克和50毫克/千克时，%T/C = 149和171）。对这些新化合物药理行为的进一步研究正在进行中。
